3-(2-Methylthio-2-tertiary aminoacetyl)-5-phenylisoxazoles

Details 3-(2-Methylthio-2-tertiary aminoacetyl)-5-phenylisoxazoles 3-(2-Methylthio-2-tertiary aminoacetyl)-5-phenylisoxazoles

1973-08-21

1976-02-17

Winters, Sherman D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260243B, 2602471M, 260268C, 260307H, 424246, 424248, 424250, 424267, 424272, C07D29512

Patent

active

039391671

ABSTRACT:
A phenylisoxazole of the formula: ##SPC1##
Wherein, Y represents a hydrogen atom, a halogen atom, an alkali metal atom or a tertiary amino group and Z represents a sulfur atom or a sulfoxide group. They are prepared by subjecting 3-alkoxycarbonyl-5-phenylisoxazole to a treatment with at least one agent selected from the group consisting where required and as necessary of dimethyl sulfoxide, a neutralizing agent, an agent capable of releasing a halogen ion and a secondary amine at a temperature ranging from about -5.degree.C to about 70.degree.C for a time period from several minutes up to about 4 hours.
The phenylisoxazoles are useful as intermediates for preparing a 3-(2-tertiary amino-1-hydroxyethyl)-5-phenylisoxazole, any of which is known as useful medicaments having a remarkable analgesic, antispasmodic, antiphretic, antiallergic, antiinflammatory, antitussive activity or the like, each reflecting the species of the substituent tertiary amino groups and generally having a very low toxicity.

REFERENCES:
patent: 3321474 (1967-05-01), Kano et al.
patent: 3321475 (1967-05-01), Kano et al.
patent: 3752819 (1973-08-01), Philippe

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