3-(2-chloro-4-(trifluoromethyl)phenoxy)-1-azetidine carboxamides

Details 3-(2-chloro-4-(trifluoromethyl)phenoxy)-1-azetidine carboxamides 3-(2-chloro-4-(trifluoromethyl)phenoxy)-1-azetidine carboxamides

1990-12-07

1992-03-10

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

548952, A61K 31395, C07D20504

Patent

active

050950142

ABSTRACT:
The present invention relates to novel 3-(2-chlor-4-trifluoromethylphenoxy)-1-azetidine carboxamides having the formula: ##STR1## wherein R1 and R2, same or different, are selected from hydrogen, C.sub.1 -C.sub.4 alkyl, and allyl.
In a series of 3-(substitutedphenoxy)-1-azetidinecarboxamides, introduction of a chlorine atom at the 2-position of the phenoxy group of the corresponding 4-trifluoromethylphenoxy-1-azetidinecarboxamides resulted in unexpected increased potency in anticonvulsant pharmacological tests.

REFERENCES:
patent: 4226861 (1980-10-01), Cale
patent: 4571393 (1986-02-01), Teng
patent: 4956359 (1990-09-01), Taylor et al.

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