3,2-Benzoxazepine derivatives

Details 3,2-Benzoxazepine derivatives 3,2-Benzoxazepine derivatives

1974-11-14

1977-08-09

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424244, 42424854, 424267, 2602433, 260268BC, 26029358, 26032634, 260471C, 260488CD, 260618D, C07D26702

Patent

active

040410480

ABSTRACT:
3,2-Benzoxazepines of the formula ##STR1## and their preparation. In formula (I), R respesents hydrogen or lower alkyl; R.sup.1 represents hydrogen, lower alkyl, lower alkenyl, hydroxy-lower alkyl, carbamyloxy-lower alkyl, acyl, amidino, carbamyl, mono- or di-substituted carbamyl; R.sup.2 may be in position 7 or 8 of the benzoxazepine ring and represents hydrogen, nitro, amino, acetamino or halo. The compounds are prepared by reacting 1,2,4,5-tetrahydro-3,2-benzoxazepine with a reactant which reacts with a secondary amino group to give substitution in the 2-position. The compounds have anti-inflammatory and central nervous system activity.

REFERENCES:
patent: 2807628 (1957-09-01), Belleau
patent: 3660387 (1972-05-01), Piffert et al.
Pifferi et al., J. Heterocyclic Chem., vol. 8, pp. 911-918 (12/1971).
Pifferi et al., J. Med. Chem., vol. 12, pp. 261-266 (1969).

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