3-(2-aminomethyl)-4-[3-trifluoromethyl)benzoyl]-3-4 dihydro-2h-1

Details 3-(2-aminomethyl)-4-[3-trifluoromethyl)benzoyl]-3-4 dihydro-2h-1 3-(2-aminomethyl)-4-[3-trifluoromethyl)benzoyl]-3-4 dihydro-2h-1

1995-02-02

1996-08-27

Datlow, Philip I.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544105, A61K 31535, C07D41306, C07D47104, C07D49504

Patent

active

055501257

ABSTRACT:
Compounds of the general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen, fluorine or chlorine atom or a methyl, C.sub.1 -C.sub.3 alkoxy or nitro group; R.sub.3 represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; R.sub.4 represents a 2,3-dihydro-1H-inden-2-yl, 2,3-dihydro-1H-inden-1-yl or 1,2,3,4-tetrahydronaphthalen-1-yl group; or alternatively R.sub.3 and R.sub.4 complete, with the nitrogen atom to which they are attached, a 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-2-yl, 1,2,3,4-tetrahydro-9H-pyrido[4,3-b]indol-3-yl, 4,5,6,7-tetrahydrothieno[2,3-c]pyrid-6-yl, 4,5,6,7-tetrahydrothieno[3,2-c]pyrid-6-yl or 2,3-dihydro-1H-isoindol-2-yl group; are useful for the treatment and prevention of cerebral disorders.

REFERENCES:
patent: 4636563 (1987-01-01), Abou-Gharbia
patent: 4977159 (1990-12-01), Sevrin et al.
patent: 5447928 (1995-09-01), Williams
Cannon, Joseph G. et al, "Conformationally Restricted Congeners of Dopamine Derived from 2-Aminoindan", J. Med. Chem., 1982, vol. 25, pp. 1442-1446.

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