3-(2,5-Dihydroxyphenyl)-alanine as a cardiac stimulant

Details 3-(2,5-Dihydroxyphenyl)-alanine as a cardiac stimulant 3-(2,5-Dihydroxyphenyl)-alanine as a cardiac stimulant

1975-03-25

1976-08-24

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

A61K 31195

Patent

active

039767825

ABSTRACT:
3-(2,5-Dihydroxyphenyl)-alanine, in its racemic form as well as the individual optical isomers thereof possess significant activity as cardiac stimulants. Various derivatives of the racemic mixture are prepared which are resolved into the component optical isomers. The racemic mixture and the enantiomers are employed in compositions which are administered as cardiac stimulants.

REFERENCES:
Journal of the American Chemical Society, 71, p. 3758 (1949).
Journal of the American Chemical Society, 76, p. 133 (1954).
Biochemical Journal, 43, p. 599 (1948).
Circulation, XLV, pp. 97-106, (1972).

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