3-(2-(4-phenylpiperazinylethyl)anilino)-isobenzofuranones, their

Details 3-(2-(4-phenylpiperazinylethyl)anilino)-isobenzofuranones, their 3-(2-(4-phenylpiperazinylethyl)anilino)-isobenzofuranones, their

1983-07-27

1986-05-20

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544376, 544377, 544392, A61K 31495, C07D24104

Patent

active

045901937

ABSTRACT:
This invention relates to 3-(2-(4-phenylpiperazinylethyl)anilino)-isobenzofuranones, their method of preparation and their use in the treatment of conditions such as hypertension, and allergies.
These compounds are characterized by the formula: ##STR1## in which R.sub.1 may be one or more substituents located at the ortho, meta, or para positions selected from the group of H, CH.sub.3, CF.sub.3, F, Cl and OCH.sub.3 ; R.sub.2 and R.sub.3 are the same or different and are H or OCH.sub.3. These compounds are in the form of free bases or their pharmaceutically safe salts. They can be obtained by a reaction between a 2-(phenylpiperazinylethyl) aniline and an aromatic aldehyde having an acid function at the ortho position of the carboxaldehyde function.
These derivatives are useful for the treatment of hypertension and allergic conditions.

REFERENCES:
Creuzet, et al., "Chemical Abstracts", vol. 101, 1984, col. 101:2331pc.

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