3-(2-(2-benzimidazolyl) benzolyloxyethyl)-4(3H)-quinazolinone

Details 3-(2-(2-benzimidazolyl) benzolyloxyethyl)-4(3H)-quinazolinone 3-(2-(2-benzimidazolyl) benzolyloxyethyl)-4(3H)-quinazolinone

1985-04-08

1986-07-08

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544286, 548330, C07D40312

Patent

active

045994153

ABSTRACT:
This invention relates to the compound 3-[2-(2-Benzimidazolyl) Benzoyloxyethyl]-4(3H)-Quinazolinone of Formula I, and a process for the preparation thereof. The compound exhibits strong analgesic activity and almost zero toxicity in laboratory mice. ##STR1## The compound of Formula I is prepared by acylation of the compound 3-(2-hydroxyethyl)-4(3H)-quinazolinone with a reactive derivative of 2-(2-benzimidazolyl)benzoic acid, preferably its imidazolide, formed by treatment of the acid of Formula III with 1,1'-carbonyldiimidazole. The compounds of Formula II and Formula III are reacted in situ, at room temperature, and in the presence of an inert organic solvent. The product compound is isolated and purified by common techniques.

REFERENCES:
patent: 4335127 (1982-06-01), Vandenberk et al.

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