3,14-Substituted-8-oxamorphinans

Details 3,14-Substituted-8-oxamorphinans 3,14-Substituted-8-oxamorphinans

1974-11-27

1976-05-25

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D49104

Patent

active

039592901

ABSTRACT:
N-Substituted-3-hydroxy-8-oxamorphinans have been found to possess potent narcotic agonist and/or antagonist activity. In particular, the compound l-N-cyclopropylmethyl-3-hydroxy-14.beta.-methyl-8-oxamorphinan has been found to possess potent narcotic antagonist and agonist activity. These compounds are prepared by total synthesis and are not derived from opium alkaloids.

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