3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles

Details 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles

1990-05-21

1991-08-20

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544230, 544369, A61K 31495, C07D41714

Patent

active

050414453

ABSTRACT:
This invention relates to 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles of the formula ##STR1## where R.sub.1 and R.sub.2 are each independently hydrogen or loweralkyl or R.sub.1 and R.sub.2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane or cycloheptane ring; R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane or cycloheptane ring; R.sub.5 is hydrogen, loweralkyl, alkanoyl or aroyl; X is hydrogen, halogen, loweralkyl or alkoxy; m is an integer of 1 to 3, the pharmaceutically acceptable acid addition salts thereof and where applicable, the optical, geometrical and stereoisomers and racemic mixtures thereof. The compounds of this invention are useful as antipsychotic agents.

REFERENCES:
patent: 4100282 (1978-07-01), Renth et al.
patent: 4448777 (1984-05-01), Heinemann et al.
patent: 4775761 (1988-10-01), Strupczewski
patent: 4933453 (1990-06-01), Hrib et al.

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