3-(1-substituted-4-piperazinyl)-1H-indazoles

Details 3-(1-substituted-4-piperazinyl)-1H-indazoles 3-(1-substituted-4-piperazinyl)-1H-indazoles

1989-09-11

1990-09-04

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544230, 544232, 544366, 544368, A61K 31495, C07D40114, C07D40304, C07D40314

Patent

active

049545035

ABSTRACT:
This invention relates to 3-(1-substituted-4-piperazinyl)-1H-indazoles having the following formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, arylloweralkyl, acyl, cycloalkylloweralkylene, and phenylsulfonyl: and R.sub.2 is hydrogen, lower alkyl, hydroxyloweralkyl of the formula ##STR2## where Z is selected from hydrogen, halogen, loweralkoxy, CF.sub.3, NO.sub.2, and NH.sub.2 ; ##STR3## where Z is as defined above; ##STR4## where Z is as defined above; ##STR5## where R.sub.3 and R.sub.4 are each independently hydrogen and loweralkyl; ##STR6## where Z is as defined above; ##STR7## where R' and R" are each independently hydrogen and loweralkyl; X is hydrogen, loweralkyl, hydroxyl, halogen, loweralkoxy, CF.sub.3, NO.sub.2 and amino; n is an integer of 1 to 4, with the further proviso that R.sub.2 is not loweralkyl when R.sub.1 is hydrogen or acyl and X is chloro; the pharmaceutically acceptable acid addition salts thereof and where appropriate the geometric isomers, the stereoisomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic and antipsychotic agents.

REFERENCES:
patent: 4260610 (1981-04-01), Regnier et al.
patent: 4452799 (1984-06-01), Temple, Jr. et al.
patent: 4524206 (1985-06-01), New et al.
patent: 4536578 (1985-08-01), Davis et al.
patent: 4590196 (1986-05-01), Smith et al.
patent: 4737500 (1988-04-01), Soy
Strupczewski et al., Chem. Abst. 110-212857z (1989).
Wrzeciono et al., Chem. Abst. 112-55915p (1990).
Wrzeciono et al., CA 106-176242b, Chemical Abstracts, 11th Col. Index, (vol. 96-105, 1982-1986, p. 34189cs).
Lowe et al., CA 110-39024a (1989).
Wrzeciono et al., CA 111-77999a (1989).

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