3-[1-Hydroxy-2-(3- or 4-hydroxypiperidino)ethyl]-5-phenylisoxazo

Details 3-[1-Hydroxy-2-(3- or 4-hydroxypiperidino)ethyl]-5-phenylisoxazo 3-[1-Hydroxy-2-(3- or 4-hydroxypiperidino)ethyl]-5-phenylisoxazo

1974-08-12

1976-01-13

Winters, Sherman D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260307H, 424267, C07D21140

Patent

active

039324265

ABSTRACT:
3-[1-Hydroxy-2-(3- or 4-hydroxypiperidino)ethyl]-5-phenylisoxazole synthesized from 3-(1,2-epoxyethyl)-5-phenylisoxazole or 3-(1-hydroxy-2-active group-substituted ethyl)-5-phenylisoxazole with 3- or 4-hydroxypiperidine, or 3-(3- or 4-hydroxypiperidino)acetyl-5-phenylisoxazole or 3-(3- or 4-ketopiperidino)acetyl-5-phenylisoxazole by reduction showing strong analgesic and anti-inflammatory activities with low toxicity.

REFERENCES:
J. Med. Chem. 10: 411-418 (1967), Kano et al.

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