3-(1-Halo-2-oxoethyl)cephalosporin intermediates

Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent

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544 24, 544 25, 544 28, C07D50124

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active

045543500

ABSTRACT:
New cephalosporin derivatives of the formula: ##STR1## in which R is an amino-protecting radical, R' is a protected carboxyl radical, Hal is a halogen atom, R.sub.a, R.sub.b and R.sub.c are hydrogen atoms, or R.sub.a is a protected carboxyl radical and R.sub.b and R.sub.c, which are identical or different, are hydrogen atoms, or C.sub.1 -C.sub.4 alkyl radicals, or together form a C.sub.2 -C.sub.5 alkylene radical, and n=0 or 1, their isomeric forms and mixtures thereof, are useful for the preparation of cephalosporins which have antibacterial properties.

REFERENCES:
patent: 4415735 (1983-11-01), Farge et al.
Organic Chemistry by Hendrickson et al, p. 208.
Advanced Organic Chemistry, by J. March, pp. 86, 89, 105, and 113.

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