3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Details 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

1991-09-20

1992-12-08

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D47104

Patent

active

051699478

ABSTRACT:
Compounds of the formula ##STR1## wherein one of A, B, D and E is N and the remaining three atoms are C; R.sup.1 and R.sup.2 are independently selected from hydrogen and C.sub.1 to C.sub.6 alkyl; and R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are independently selected from hydrogen, halogen, hydroxy, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.8 alkoxy, phenyl-C.sub.1 -C.sub.6 alkoxy, phenoxy, --NR.sup.7 R.sup.8 wherein R.sup.7 and R.sup.8 are independently selected from hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkanoyl, and COOR.sup.9 wherein R.sup.9 is hydrogen or C.sub.1 -C.sub.6 alkyl, cyano, COOR.sup.10 wherein R.sup.10 is hydrogen or C.sub.1 -C.sub.6 alkyl, and CONR.sup.11 R.sup.12 where R.sup.11 and R.sup.12 are independently selected from hydrogen and C.sub.1 -C.sub.6 alkyl, and the pharmaceutically acceptable salts thereof. The compounds are useful psychotherapeutics and may be used in treating obesity, depression and disorders wherein aggression is a symptom.

REFERENCES:
patent: 3993764 (1976-11-01), Dumont et al.
patent: 4196209 (1980-04-01), Dumont et al.
patent: 4232031 (1980-11-01), Dumont et al.
patent: 4278677 (1981-07-01), Nedelec et al.
patent: 5051412 (1991-09-01), Macor
Kennet et al., Eur. Jl. of Pharmacology, 141, 429-35 (1987).
Freter, K., J. Org. Chem., 40, 2525-9 (1975).
Bendotti et al., Life Sciences, 41, 635-42 (1987).
Hutson et al., Psychopharmacology, 95, 550-52 (1988).

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