Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1972-01-25
1976-10-05
Myers, Jane S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260485H, C07C 6940
Patent
active
039844617
ABSTRACT:
A two-step method for the preparation of 3-0-(beta-carboxypropionyl-18-beta-glycyrrhetic acid (carbenoxolone) is disclosed, which comprises the steps of condensing beta-glycyrrhetic acid with anhydrous beta-carbobenzyloxypropionic acid (or a derivative thereof such as its chloride or anhydride), the result being 3-O-(beta-carbobenzyloxypropionyl)-11-oxo-18-beta-olean-12-en-30-oic acid, the latter compound being then debenzylated with hydrogen under normal temperature and pressure conditions, in an alcoholic solvent (alcohols having from C.sub.1 to C.sub.5) and in the presence of catalytic amounts of a noble metal (e.g. palladium), thus obtaining the expected compound.
REFERENCES:
Technique of Organic Chemistry, vol. II, Interscience Publishers, Inc., N.Y., pp. 123-124 (1956).
I.S.F. S.p.A.
Myers Jane S.
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