(2S)-amino(phenyl)acetic acid and derivatives as α 2...

Details (2S)-amino(phenyl)acetic acid and derivatives as α 2... (2S)-amino(phenyl)acetic acid and derivatives as α 2...

2008-04-08

2008-04-08

Marschel, Ardin (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C514S282000

Reexamination Certificate

active

10752943

ABSTRACT:
The present invention relates to a method for treating pain, reflex sympathetic dystrophy, spasticity, and bipolar disorder using ligands of the α2δ voltage-gated calcium channel, wherein the ligand comprises (2s)-aminophenyl acetic acid and derivatives.

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Gee et al., “The novel anticonvulsant drug, gabapentin (neurontin), binds to the α2δ subunit of a calcium channel,” J. Biol. Chem. 271:5768-5776 (1996).
Kim et al., “An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat,” Pain 50:355-363 (1992).
Prescott, Ed., Methods in Cell Biology, vol. XIV, Academic Press, New York, N.Y. p. 33 et seq. (1976).

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