'(2S)-(5-amino-1,2-dihydro-2-methyl-3-phenylpyrido(3,4 -b)pyrazi

Details '(2S)-(5-amino-1,2-dihydro-2-methyl-3-phenylpyrido(3,4 -b)pyrazi '(2S)-(5-amino-1,2-dihydro-2-methyl-3-phenylpyrido(3,4 -b)pyrazi

1988-04-04

1989-09-12

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544350, C07D21375, A61K 31495

Patent

active

048660590

ABSTRACT:
The (2S)-(-)-isomer of (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl)arbamic acid, ethyl ester is significantly more potent than either the (2R)-(+)-isomer or the (R,S)-(.+-.)- racemic mixture in inhibiting mitotic cell division of L1210 leukemia cells.

REFERENCES:
patent: 4052510 (1977-10-01), Simpson et al.
patent: 4450160 (1984-05-01), Temple, Jr. et al.
patent: 4600716 (1986-07-01), Temple et al.
patent: 4645840 (1987-02-01), Temple et al.
Morrison and Boyd, Organic Chemistry, 1981, pp. 126-127.

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