(2S,4S)-4-(piperazin-1-yl)pyrrolidine-2-methanone derivatives

Details (2S,4S)-4-(piperazin-1-yl)pyrrolidine-2-methanone derivatives (2S,4S)-4-(piperazin-1-yl)pyrrolidine-2-methanone derivatives

2006-12-07

2008-12-16

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S295000

Reexamination Certificate

active

07465732

ABSTRACT:
The invention provides compounds of formula (I),or a pharmaceutically acceptable salt of said compound, or a solvate of said compound or salt, wherein R1, R2, R3, HET, n, Q, X, Y, and Z are as described herein; compositions thereof; and uses thereof including treating Type 2 diabetes.

REFERENCES:
patent: 2005/0256310 (2004-05-01), Hulin et al.
patent: 2006/0079498 (2005-11-01), Hulin et al.
patent: 2428271 (2002-05-01), None
patent: 1308439 (2003-05-01), None
patent: 1426366 (2004-06-01), None
patent: 1535906 (2005-06-01), None
patent: 04 026820 (2004-01-01), None
patent: 05 139107 (2005-06-01), None
patent: 2005-170792 (2005-06-01), None
patent: WO 9534538 (1995-12-01), None
patent: WO 02 076450 (2002-10-01), None
patent: WO 03 000250 (2003-01-01), None
patent: WO 03 002531 (2003-01-01), None
patent: WO 03 002553 (2003-01-01), None
patent: WO 03 035057 (2003-05-01), None
patent: WO 03 057144 (2003-07-01), None
patent: WO 03 057666 (2003-07-01), None
patent: WO 03 095425 (2003-11-01), None
patent: WO 03 101449 (2003-12-01), None
patent: WO 03 101958 (2003-12-01), None
patent: WO 2004 007446 (2004-01-01), None
patent: WO 2004 043940 (2004-05-01), None
patent: WO 2004 046106 (2004-06-01), None
patent: WO 2004 050022 (2004-06-01), None
patent: WO 2004 071454 (2004-08-01), None
patent: WO 2004 092128 (2004-10-01), None
patent: WO 2004 110436 (2004-12-01), None
patent: WO 2004 112701 (2004-12-01), None
patent: WO 2005 009956 (2005-02-01), None
patent: WO 2005 023762 (2005-03-01), None
patent: WO 2005 042533 (2005-05-01), None
patent: WO 2005 044195 (2005-05-01), None
Caldwell, C.G., et al., “Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors”,Bioorganic&Medicinal Chemistry Letters, vol. 14, pp. 1265-1268 (2004).
Lu, I., et al., “Glutamic acid Analogues as potent dipeptidyl peptidase IV and 8 inhibitors”,Bioorganic&Medicinal Chemistry Letters, vol. 15, pp. 3271-3275 (2005).
Mastracchio, A., et al., “Heterocycle Fused Cyclohexylglycine Derivatives as Novel Dipeptidyl Peptidase-IV Inhibitors”,Heterocycles, vol. 82, pp. 203-206 (2004).
Augustyns, KJL., et al., “Pyrrolidides:: synthesis and structure-activity relationship as inhibitors of dipeptidyl peptidase IV”,Eur J Med Chem., vol. 32, pp. 301-309 (1997).
Sakashita, H., et al., “1-((S)-γ-Substituted prolyl)-(S)-2-cyanopyrrolidine as novel series of highly potent DPP-IV inhibitors”,Bioorganic&Medicinal Chemistry Letters, vol. 15, pp. 2441-2445 (2005).
Xu, J., et al., “Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors”,Bioorganic&Medicinal Chemistry Letters, vol. 15, pp. 2533-2536 (2005).
Fukushima, H., “Synthesis and structure-activity relationships of potent 3- or 4-substituted-2-cyanopyrrolodine dipeptidyl peptidase IV inhibitors”,Bioorganic&Medicinal Chemistry, vol. 12, pp. 6053-6061 (2004).

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