Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1994-07-14
1997-07-08
McKane, Joseph K.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544243, 544182, 558 45, 546 23, C07F 96524, C07F 96512, C07F 940
Patent
active
RE0355585
ABSTRACT:
The invention relates to the new compound (2R)-2-[di(2-propyl)phosphonylmethoxy]-3-p-toluenesulfonyloxy-1-trimethyla cetoxypropane and the method of producing it. The compound may be used for producing (S)-N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of the heterocyclic purine and pyrimidine bases of antiviral activity.
REFERENCES:
patent: 4659825 (1987-04-01), Holy et al.
patent: 4808716 (1989-02-01), Hol et al.
patent: 4816447 (1989-03-01), Ashton et al.
patent: 4868187 (1989-09-01), Ogilvie
patent: 4927830 (1990-05-01), Townsend et al.
patent: 4968686 (1990-11-01), Townsend et al.
patent: 5047533 (1991-09-01), Reist et al.
patent: 5142051 (1992-08-01), Holy et al.
patent: 5476938 (1995-12-01), Vernishetti et al.
Bronson et al., "Synthesis and Antiviral Activity of Phosphonylmethoxyethyl Derivatives of Purine and Pyrimidine Bases," ACS Symposium Series 401:72-87 (1989).
Chu et al, "Chemistry and Antiviral Activities of Acyclonucleosides," J Het Chem 23:289-319 (1986).
Holy et al, "Synthesis of (3-Hydroxy-2-Phosphonylmethoxypropyl) Derivatives of Heterocyclic Bases," Collect Czech Chem Commun 54:2470-2501 (1989).
Holy et al, "Synthesis of N-(2-Phosphonylmethoxyethyl) Derivatives of Heterocyclic Bases," Collect Czech Chem Commun 54:2190-2210 (1989).
Holy et al., "Phosphonylmethyl Ethers of Nucleosides and Their Acyclic Analogues," ACS Symposium Series 401:57-71 (1989).
Holy et al., "Acyclic Nucleoside and Nucleotide Analogues Derived from 1-Deaza and 3-Deazaadenine," 3rd Intl Conf Antiviral Res No. 30, p. 55 (Apr. 22-27, 1990).
Holy, A., "Structure-Acitivity Studies in the Series of Acyclic Nucleotide Analogues," Kem Ind 38(10):457-462 (1989).
Webb, R.R. et al. Tetrahedron Lett. 1988, 29, 5475-5478.
Alexander Petr
Dvorakova Hana
Holy Antonin
Ambrose Michael G.
Hensley Max D.
Institute of Organic Chemistry and Biochemistry of the Academy o
McKane Joseph K.
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