(2R)-2-[di(2-propyl)phosphonylmethoxy]-3-p-to luenesulfonyloxy-1

Details (2R)-2-[di(2-propyl)phosphonylmethoxy]-3-p-to luenesulfonyloxy-1 (2R)-2-[di(2-propyl)phosphonylmethoxy]-3-p-to luenesulfonyloxy-1

1991-07-12

1992-07-14

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544243, 544244, 546 23, 558124, 558179, C07F 96521, C07F 96509, C07F 96506, C07F 940

Patent

active

051304279

ABSTRACT:
The invention relates to the new compound (2R)-2-[di(2-propyl)phosphonylmethoxy]-3-p-toluenesulfonyloxy-1-trimethyla cetoxypropane and the method of producing it. The compound may be used for producing (S)-N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of the heterocyclic purine and pyrimidine bases of antiviral activity.

REFERENCES:
patent: 4968686 (1990-11-01), Townsend et al.
Webb, R. R. et al. Tetrahedron Letters, vol. 29, pp. 5475-5478 (1988).

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