2H-[1]benzoxepino[5,4-b]-1,4-oxazine derivatives

Details 2H-[1]benzoxepino[5,4-b]-1,4-oxazine derivatives 2H-[1]benzoxepino[5,4-b]-1,4-oxazine derivatives

1987-10-29

1988-08-23

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 99, C07D49804

Patent

active

047662123

ABSTRACT:
Derivatives of 2H-[1]benzoxepino[5,4-b]-1,4-oxazine, such as trans-3,4,4a,5,6,11b-hexahydro-10-methoxy-2H-[1]benzoxepino[5,4-b]-1,4-oxa zine, are prepared by acylating a trans-4-amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol, cyclizing the resulting chloroacetamido alcohol, reducing the 1,4-oxazine-3(4H)-one so obtained, acylating the resulting 2H-[1]-benzoxepino[5,4-b]-1,4-oxazine, and reducing the N-acryl-2H-[1]benzoxepino[5,4-b]-1,4-oxazine so obtained. The novel compounds disclosed herein possess useful antihypertensive properties.

REFERENCES:
patent: 4318910 (1982-03-01), Nedelec et al.
patent: 4349548 (1982-09-01), Jones

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