2H-1-benzopyran-2-one derivatives, processes for the preparation

Details 2H-1-benzopyran-2-one derivatives, processes for the preparation 2H-1-benzopyran-2-one derivatives, processes for the preparation

1985-07-16

1987-06-02

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544376, A61K 31495, C07D40512

Patent

active

046704396

ABSTRACT:
The present invention provides 2H-1-benzopyran-2-one derivatives of the general formula: ##STR1## wherein either R.sub.1 is a lower alkyl radical, optionally substituted by phenyl, which can be substituted by lower alkyl, lower alkoxy, hydroxyl or halogen, and R.sub.2 is trifluoromethyl, cyano, hydroxymethyl, alkoxymethyl, acyloxymethyl, halogenomethyl, aminomethyl, mono- or dialkylaminomethyl, acyl, carboxyl, alkoxycarbonyl or carbamoyl, which can be mono- or disubstituted by lower alkyl; or R.sub.1 is trifluoromethyl, cyano, hydroxymethyl, alkoxymethyl, acyloxymethyl, halogenomethyl, aminomethyl, mono- or dialkylaminomethyl, acyl, carboxyl, alkoxycarbonyl or carbamoyl, which can be mono- or disubstituted by lower alkyl, and R.sub.2 is a lower alkyl radical, optionally substituted by phenyl, which can be substituted by lower alkyl, lower alkoxy, hydroxyl or halogen, and R.sub.3 is a phenyl or benzyl radical which can be substituted by lower alkyl, lower alkoxy, hydroxyl or halogen; and the pharmacologically acceptable salts thereof.
The present invention also provides processes for the preparation of these 2H-1-benzopyran-2-one derivatives and pharmaceutical compositions containing them.

REFERENCES:
patent: 3052679 (1962-09-01), Cavallini et al.
patent: 3311636 (1967-03-01), Moffett
patent: 3541097 (1970-11-01), Beyerle et al.
patent: 3810898 (1974-05-01), Witte et al.
Brit. J. Pharmacol. (1960) 15,290 Versuchsanordnung zu Entersuchungen an der Bronchialmuskulatur von Heribert Konzett und Richard Rossler.
Tetrahedron Letters No. 15, pp. 1227-1228, 1976, Pergamon Press, Great Britain International Archives of Allergy and Applied Immunology.
Int. Arch. Allergy 45: 467-478 (1973).

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