2H-1,3,4-benzotriazepin-2-ones

Details 2H-1,3,4-benzotriazepin-2-ones 2H-1,3,4-benzotriazepin-2-ones

1991-04-12

1992-02-25

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540501, C07D25504, A61K 3155

Patent

active

050913816

ABSTRACT:
Peripheral benzodiazepines (BZDs) are useful in treating disorders caused by abnormal level of peripheral benzodiazepene receptor activity and having, in one aspect, the formula: ##STR1## wherein each X, X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5, X.sub.6, and X.sub.8, independently, is hydrogen, halogen (F, Cl, Br, I), C.sub.1 -C.sub.4 straight or branched alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, hydroxy, nitro, cyano, amino, or trifluoromethyl; R.sub.1 =H, C.sub.1 -C.sub.4 alkyl, cyclo C.sub.3 -C.sub.5 alkyl, C.sub.1 -C.sub.4 alkenyl, CH.sub.2 --CO.sub.2 H, or CH.sub.3 --C.dbd.O; R.sub.2 =a member of the group of the formula (Ia) ##STR2## wherein each R.sub.3, R.sub.4, R.sub.8, R.sub.9, R.sub.10 and R.sub.11, independently, can be any of the groups listed as possibilities for X.sub.1 -X.sub.8, and can be attached at any available ring carbon atom, said R.sub.2 group being bonded to (CH.sub.2) in via any available ring carbon atom; n=0 or 1; and m=an integer between 1 and 4 provided that m is at least 1 when n=0.

REFERENCES:
Max Busch "Berichte", vol. 27, pp. 2897-2904 (1894).

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