27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002,...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

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C435S252300, C435S252330, C435S325000, C435S254100, C435S302100, C536S023200

Reexamination Certificate

active

11429599

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
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patent: WO 01/55318 (2001-08-01), None
patent: WO 01/57182 (2001-08-01), None
patent: WO 02/08399 (2002-01-01), None
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Lawson, N.D., et al., “Mus Musculus Calcium/Calmodulin Dependent Protein Kinase Kinase Alpha (Camkk) mRNA, Complete Cds,” Nov. 16, 1999, (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Dec. 14, 2005], Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AF117384.
Fujisawa, H., et al., “Rattus Norvegicus mRNA for Ca/Calmodulin-Dependent Protein Kinase Kinase Alpha, CaM-Kinase Kinase Alpha, Complete Cds,” Feb. 24, 1999, (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Dec. 14, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AB023658.
Yano, Shigetoshi, et al., “Calcium Promotes Cell survival Through CaM-K Kinase Activation of the Protein-Kinase-B Pathway,”Nature, vol. 396, (Dec. 10, 1998), pp. 584-587.
Okuno, Sachiko., et al., “Ca2+/Calmodulin-Dependent Protein Kinase IV Kinase Isoform [Rats, Brain, mRNA, 3429 nt],” Feb. 11, 1997, (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Dec. 14, 2005], Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. S83194.
Tokumitsu, Hiroshi, et al, “Ca2+/Calmodulin-Dependent Protein Kinase Kinase,” Sep. 15, 1995 (sequence) GenPept [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Dec. 14, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenPept Accession No. AAC42070.
Fujisawa, H., et al., “Ca/Calmodulin-Dependent Protein Kinase Kinase Alpha, CaM-Kinase Kinase Alpha [Rattus Norvegicus],” Feb. 24, 1999, (sequence) GenPept [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Dec. 14, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenPept Accession No. BAA75246.
Okuno, Sachiko., et al., “Ca2+/Calmodulin-Dependent Protein Kinase IV Kinase Isoform; CaM-Kinase Kinase Alpha [Rattus sp.],” Feb. 11, 1997, (sequence) GenPept [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Dec. 14, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenPept Accession No. AAB46910.
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Tokumitsu, Hiroshi, et al., “Calcium/Calmodulin-Dependent Protein Kinase Kinase 1 (Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha) CaM-Kinase Kinase Alpha) (CaM-KK alpha) (CaMKK Alpha) (alpha CaMKK) (CaMKK 1) (CaM-Kinase IV Kinase),” Created Feb. 1, 2005, (sequence) GenPept [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Dec. 14, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenPept Accession No. P97756.

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