2786, a novel human aminopeptidase

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C536S023500, C435S320100

Reexamination Certificate

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10767308

ABSTRACT:
The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.

REFERENCES:
patent: 4185156 (1980-01-01), Umezawa et al.
Fukasawa et al (J. Biol. Chem. 271(48): (1996).
Fukasawa et al (Biochem J. 339: 497-502, 1999).
Rudinger (In Peptide Hormones J.A. Parsons, Ed. University Park Press, Baltimore, 1976, pp. 5-7).
Ngo et al (In The Protein Folding Problem and Tertiary Structure Prediction, K. Merz Jr. and S. Legrand, Eds. Birkhauser, Boston, 1994, p. 491-495).
Belhacene et al (Eur. J. Immunol. 23 (8), 1948-1955 (1993)).
NCBI output retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=Protein&list—uids=40316915&dopt=GenPept on Aug. 25, 2005.
Anderson, “Human Gene Therapy,”Nature, Apr. 30, 1998, vol. 392 Supp., pp. 25-30.
Beattie et al., Abstract, “The Use of Multiple Pin Peptide Synthesis in an Analysis of the Continuous Epitopes Recognized by Various Anti-(recombinant bovine growth hormone) Sera,”European Journal of Biochemistry, Nov. 15, 1992, pp. 59-66, vol. 210, No. 1.
Cadel et al, “Aminopeptidase B from the Rat Testis is Bifunctional Enzyme Structurally Related to Leukotriene-A4Hydrolase,”Proc. Natl. Acad. Sci. USA, 1997, pp. 2963-2968, vol. 94.
Dedinsky et al., “Antigenic Determinants of Cytochrome P450 Superfamily and Their Classification,” 8thRussia Cytochrome P450 Int. Conf., 1994, Abstract No. 119832.
Draoui, et al., “Expression and Retinoid Modulation N-argine Dibastic Convertase and an Aminopeptidase-B in Human Neuroblastoma Cell Lines,”Journal of Neuro-Oncology, 1997, pp. 99-106, vol. 31, No. 12.
Foulon, et al., “Aminopeptidase B (EC 3.4.11.6),” International Journal of Biochemistry & Cell Biology, Jul. 1999, pp. 747-750, vol. 31, No. 7.
Fukasawa, et al, “Molecular Cloning and Expression of Rat Liver Aminopeptidase B,” Journal of Biological Chemistry, Nov. 29, 1998, pp. 30731-30735, vol. 271, No. 48.
Ngo et al., “Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox,”The Protein Folding Problem and Tertiary Structure Prediction, 1994, pp. 491-495.
Piesse et al., “Human Aminopeptidase B on Chromosome 1q32.2:cDNA, Genomic Structure and Expression,” Direct Submission May 1999, EBI UK Accession No. Q9H1D4.
Rudinger, “Characteristics of the Amino Acids and Components of a Peptide Hormone Sequence,”Peptide Hormones, Jun. 1976, pp. 5-7/.
Sancho, et al., “Role of UEV-1, an Inactive Variant of the E2 Ubiquitin-Conjugating Enzymes, in In Vitro Differentiation and Cell Cycle Behavior of HT-29-M6 Intestinal Mucosecretory Cells,”Molecular and Cellular Biology, Jan. 1998, pp. 576-589, vol. 18, No. 1.
Verma, et al., “Gene Therapy—Promises, Problems and Prospects,”Nature, Sep. 18, 1997, vol. 389, pp. 239-242.
Piesse, C., et al., “Arginyl Aminopeptidase (Aminopeptidase B) [Homo sapiens],” May 14, 2005 (sequence) GenPept [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Aug. 25, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>, GenPept Accession No. NP—064601.3.
Piesse, C., et al., “Arginyl Aminopeptidase (Aminopeptidase B) [Homo sapiens],” Dec. 21, 2003 (sequence) GenPept [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Dec. 15, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenPept Accession No. NP—064601.2.
Bloecker, H., et al., “Hypothetical Protein DKFZp547H084 [Homo sapiens],” Nov. 2, 2000 (sequence) GenPept [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Dec. 15, 2005]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenPept Accession No. NP—064601.1.
Strausberg, Robert, “tq67b04.x1 NCI—CGAP—Lu19Homo sapienscDNA Clone IMAGE:2213839 3′ Similar to SW:AMPB—RAT O09175 Aminopeptidase B ;, mRNA Sequence,” Dec. 14, 1999 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 9, 2006]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AI582355.
Strausberg, Robert, “xg72f09.x1 NCI—CGAP—Ut4Homo sapienscDNA Clone IMAGE:2633897 3′ Similar to SW:AMPB—RAT O09175 Aminopeptidase B ;, mRNA Sequence,” Nov. 12, 1999 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 9, 2006]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AW167220.
Sugano, S., et al., “Homo sapienscDNA: FLJ22991 fis, Clone KAT11853, Highly Similar to HSU49278Homo sapiensUEV-1 (UBE2V) mRNA,” Sep. 12, 2003 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 9, 2006]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. AK026644.
Sancho, E., et al., “Homo sapiensUEV-1 (UBE2V) mRNA, Partial Cds,” Feb. 17, 1998 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 9, 2006]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenBank Accession No. U49278.
Wang, Y., et al., “Env-Like Protein,” Jun. 1, 2003 (sequence) GenPept [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 9, 2006]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenPept Accession No. Q9NP17.
Piesse, C., et al, “Aminopeptidase B (Ap-B) (Arginyl Aminopeptidase) (Arginine Aminopeptidase),” Created on Feb. 28, 2003 (sequence) GenPept [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Jan. 9, 2006]. Retrieved from the Internet: URL: http://www.ncbi.nlm.nih.gov/>. GenPept Accession No. Q9H4A4.

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