27411, a novel human PGP synthase

Details 27411, a novel human PGP synthase 27411, a novel human PGP synthase

2006-04-18

2006-04-18

Rao, Manjunath (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S440000, C435S006120, C435S069100, C435S183000, C536S023500, C536S023200, C536S023400, C530S350000

Reexamination Certificate

active

07029895

ABSTRACT:
The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC 17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: WO 01/02568 (2001-01-01), None
Chang, S. C., et al, “The PELI Gene (Renamed PGS1) Encodes the Phosphatidylgycero-Phosphate Synthase ofSaccharomyces Cerevisiae,”The Journal of Biological Chemistry,Apr. 17, 1998, pp. 9829-9836, vol. 273(16).
Gopalakrishnan, A. S., et al., “Structure and Express of the Gene Locus Encoding the Phosphatidylglycerophosphate Synthase ofEscherichia coli,” The Journal of Biological Chemistry, Jan. 25, 1986, pp. 1329-1338, vol. 261(3).
Kawasaki, K., et al., “Isolation of a Chinese Hamster Ovary (CHO) cDNA Encoding the Phosphatidylglycerophosphate (PGP) Synthase, Expression of Which Corrects the Mitochondrial Abnormalities of a PGP Synthase-Defective Mutant of CHO-K1 Cells,”The Journal of Biological Chemistry,Jan. 15, 1999, pp. 1828-1834, vol. 274(3).
BIOSIS Database Report for Accession No. PREV19766057954, 1978 (XP002180326).

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