27-hydroxyrapamycin and derivatives thereof

Details 27-hydroxyrapamycin and derivatives thereof 27-hydroxyrapamycin and derivatives thereof

1993-07-22

1994-04-12

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

540456, C07D49816, A61K 31695

Patent

active

053026004

ABSTRACT:
This invention provides a compound of formula I, ##STR1## and 27-substituted derivatives thereof which are useful as immunosuppressive, anti-inflammatory, antifungal, antitumor, and antiproliferative agents. The compound depicted by formula I is named 27-hydroxyrapamycin, and may also be referred to as 27-deoxo-27-hydroxyrapamycin.

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