26,28-methylene-1.alpha.,25-dihydroxyvitamin D.sub.2 compounds

Details 26,28-methylene-1.alpha.,25-dihydroxyvitamin D.sub.2 compounds 26,28-methylene-1.alpha.,25-dihydroxyvitamin D.sub.2 compounds

1994-12-09

1995-10-10

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

552554, C07J 900

Patent

active

054572177

ABSTRACT:
Vitamin D.sub.2 analogs in which a cyclopentane ring is introduced into the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis.

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