26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26,27

Details 26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26,27 26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26,27

1995-05-05

1996-02-27

Kestler, Kimberly J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, A61K 3159, C07C40100

Patent

active

054949068

ABSTRACT:
Vitamin D.sub.2 analogs in which a cyclopentane ring is introduced onto the 25-carbon of the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2 and its 24-epimer. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis.

REFERENCES:
patent: 4588716 (1986-05-01), DeLuca et al.
patent: 4769181 (1988-09-01), DeLuca et al.
patent: 4851401 (1989-07-01), DeLuca et al.
patent: 4973584 (1990-11-01), DeLuca et al.
patent: 5397775 (1995-03-01), DeLuca et al.

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