26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26, 2

Details 26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26, 2 26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26, 2

1994-11-10

1995-12-26

Kestler, Kimberly J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

552553, 552548, 556443, 556444, 556446, 556449, 556482, C07J 900

Patent

active

054789559

ABSTRACT:
The invention is drawn to cholesterol derivatives in which a cyclopentane ring has been introduced onto the 25-carbon of the side chain and to 24-epimers of these compounds. The compounds are useful intermediates in the production of 26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26,27-dimethylene-24-epi-1.alpha.,25-dihydroxyvitamin D.sub.2. These vitamin D derivatives are useful for the treatment of diseases such as osteoporosis.

REFERENCES:
patent: 4588716 (1986-05-01), DeLuca et al.
patent: 4769181 (1988-09-01), DeLuca et al.
patent: 4851401 (1989-07-01), DeLuca et al.
patent: 4973584 (1990-11-01), DeLuca et al.

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