25-hydroxy vitamin D.sub.3 derivatives, process for their produc

Details 25-hydroxy vitamin D.sub.3 derivatives, process for their produc 25-hydroxy vitamin D.sub.3 derivatives, process for their produc

1991-07-22

1993-04-13

Ceperley, Mary E.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

436542, 436815, G01N 33537

Patent

active

052022668

ABSTRACT:
A novel 25-hydroxy vitamin D.sub.3 amino acid derivative of the formula ##STR1## wherein R.sub.1 is C.sub.1-10 alkylene, is produced by removing a protective group for the amino group, e.g. 9-fluorenylmethyloxycarbonyl, in the presence of a base in an inert solvent. A radioisotope iodine-labeled residue is then attached to the amino group to produce a derivative useful in the assay of 25-hydroxy vitamin D.sub.3 in a specimen.

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Yamamoto et al., J. of Biochem., vol. 98, No. 4 (1985) pp. 991-998, "Monoclonal Antibody for Calcitriol (.alpha., 25-Dihydroxyvitamin D.sub.3)".
Vitamin, 55(12), (1981) pp. 595-605.
M. Tanabe et al., J. Nutr. Sci. Vitaminol. (Tokyo), 37(2), 139-47 (1991).

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