Organic compounds -- part of the class 532-570 series – Organic compounds – 9,10-seco-cyclopentanohydrophenanthrene ring system or...
Patent
1988-10-14
1991-12-24
Waddell, Frederick E.
Organic compounds -- part of the class 532-570 series
Organic compounds
9,10-seco-cyclopentanohydrophenanthrene ring system or...
514167, C07C40100, A61K 3159
Patent
active
050754653
ABSTRACT:
A novel 25-hydroxy vitamin D.sub.3 amino acid derivative of the formula ##STR1## wherein R.sub.1 is C.sub.1-10 alkylene, is produced by removing a protective group for the amino group, e.g. 9-fluorenylmethyl-oxycarbonyl, in the presence of a base in an inert solvent. A radioisotope iodine-labeled residue is then attached to the amino group to produce a derivative useful in the assay of 25-hydroxy vitamin D.sub.3 in a specimen.
REFERENCES:
patent: 4119647 (1978-10-01), Liebman et al.
patent: 4269777 (1981-05-01), De Luca et al.
patent: 4424161 (1984-01-01), Holick
patent: 4836957 (1989-06-01), Nemoto et al.
"Monoclonal Antibody for Calcitriol" (1.alpha.,25-Dihydroxyvitamin D.sub.3), Journal of Biochemistry, vol. 98, No. 4, 1985, by I. Yamamoto et al., pp. 991-998.
"Vitamin", 55(12), 1981, pp. 595-605, with partial English translation.
Ikuta Shigeru
Nakagawa Nobuaki
Tanabe Miyuki
Henley III Raymond J.
Toyo Jozo Kabushiki Kaisha
Waddell Frederick E.
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