25-Hydroxy-24-oxocholestane derivatives and preparation thereof

Details 25-Hydroxy-24-oxocholestane derivatives and preparation thereof 25-Hydroxy-24-oxocholestane derivatives and preparation thereof

1980-02-15

1981-09-29

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 900

Patent

active

042922496

ABSTRACT:
This invention relates to novel 25-hydroxy-24-oxocholestane derivatives and a process for preparing them.
The novel 25-hydroxy-24-oxocholestane derivatives of this invention can easily be converted to 24,25-dihydroxycholecalciferol or 1.alpha.,24,25-trihydroxycholecalciferol which is known as useful for medicine controlling the calcium metabolism of warm-blooded animals. Moreover, 25-hydroxy-24-oxocholestane derivatives can be converted to novel 25-hydroxy-24-oxocholecalciferol expressed by the following formula ##STR1## and novel 1.alpha.,25-dihydroxy-24-oxocholecalciferol of the formula ##STR2## which are useful for medicine. The new 25-hydroxy-24-oxocholestane derivatives in the present invention are very useful as the intermediates for the synthesis of a variety of active vitamin D.sub.3.

REFERENCES:
patent: 3936478 (1976-02-01), Takeshita et al.
patent: 4199577 (1980-04-01), Takeshita et al.

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