25-Desacetyl rifamycins

Details 25-Desacetyl rifamycins 25-Desacetyl rifamycins

1967-10-30

1980-02-12

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424244, 42424854, 424250, 424267, 424274, C07D49108

Patent

active

041883217

ABSTRACT:
The invention is concerned with a new class of rifamycins, namely, the 25-desacetylrifamycins, and with a process for their preparation. The new compounds display antibacterial activity quite similar to that shown by the parent 25-acetylrifamycins, and are characterized by a higher solubility and a lower toxicity than the parent substances.

REFERENCES:
patent: 3338888 (1967-08-01), Bickel et al.
patent: 3342810 (1967-09-01), Maggi et al.
patent: 3349082 (1967-10-01), Maggi et al.
Maggi et al., "Experientia" vol. 24, pp. 209-211 (1968).
Antimicrobial Agents and Chemotherapy--1966, edited by Gladys L. Hobby (1967), Title Page and Other Introductory pp. V and VI.
Bickel et al., II, "Antimicrobial Agents and Chemotherapy" 1967 red at a meeting of the American Society for Microbiology, Philadelphia, Pa., Oct. 26-28 (1966).
Fieser et al., "Organic Chemistry" 3rd Edition, p. 178 (Reinhold) (1956).

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