25-Carboxylic acid derivatives in the vitamin D series, process

Details 25-Carboxylic acid derivatives in the vitamin D series, process 25-Carboxylic acid derivatives in the vitamin D series, process

1993-10-06

1996-12-10

Prior, Kimberly J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, C07C40100, A61K 3159

Patent

active

055831257

ABSTRACT:
New 25-carboxylic acid derivatives of general formula I, ##STR1## R.sup.19 and R.sup.19a each mean a hydrogen atom or together form an exocyclic methylene group,
R.sup.21 and R.sup.21a independently of one another mean a hydrogen atom, a chlorine or fluorine atom, an alkyl group with 1 to 4 carbon atoms, together a methylene group, together with quaternary carbon atom 20 mean a 3-7 membered, saturated or unsaturated carboxylic ring,
Y preferably means a derivatized carboxyl radical, and the other substituents have the meanings indicated in the description as well as process for their production, are described.
The new compounds have vitamin D activity as well as proliferation-inhibiting and cell-differentiating effects and are suitable for the production of pharmaceutical agents.

REFERENCES:
patent: 4022891 (1977-05-01), Takeshita et al.
patent: 5446035 (1929-08-01), Neef et al.

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