Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1994-11-08
1996-04-16
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
552653, 514170, 514171, 514168, A61K 3159
Patent
active
055082742
ABSTRACT:
A pharmaceutical composition containing 24,25-dihydroxycholecalciferol is provided. The active ingredient used in the present invention is an intrinsic and safe substance, and so does not exhibit hypercalcemia which is the side effect induced by conventional antirachitic agents, and is effective for the treatment of rickets, particularly vitamin D resistant rickets.
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Bone, vol. 6, No. 2, 1985, pp. 113-123, I. Atkin et al, "Effects of Vitamin D metabolites on healing of low phosphate, Vitamin D deficient induced rickets in rats".
Bell Biology International Reports, vol. 12, No. 5, May 1988, pp. 373-381, E. Blaugrund et al., "Responses of rachitic cartilage cells to metabolites of Vitamin D3".
Archives Of Biochemistry And Biophysics, vol. 170, No. 2, 1975, pp. 620-626, Y. Tanaka et al, "Determination of stereochemical configuration of the 24-hydroxyl group of 24,25-dihydroxyvitamin D3 . . . ".
Nagai Yumiko
Seino Yoshiki
Tanaka Hiroyuki
Criares Theodore J.
Kureha Chemical Industry Company, Ltd.
Yoshiki Seino
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