Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
2007-01-23
2007-01-23
Badio, Barbara P. (Department: 1617)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
C552S653000
Reexamination Certificate
active
10612302
ABSTRACT:
The present invention provides novel C24-sulfone analogs of 1α,25-dihydroxy vitamin D3, compositions comprising these compounds and methods of using these compounds as selective inhibitors of CYP24. In particular, the compounds of the invention are useful for treating diseases which benefit from a modulation of the levels of 1α,25-dihydroxy vitamin D3, for example, cell-proliferative disorders.
REFERENCES:
patent: 4927815 (1990-05-01), DeLuca et al.
Posner et al., “Conceptually New Sulfone Analogues of the Hormone 1alpha,25-Dihydroxyvitamin D3: Synthesis and Preliminary Biological Evaluation.”
Crawford Kenneth
Hatcher Mark
Jeon HeungBae
Jones Glenville
Posner Gary H.
Badio Barbara P.
Cytochroma Inc.
Johns Hopkins University
Rothwell, Figg, Ernst & Manbeck pc
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