Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1992-07-08
1993-03-16
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
552541, 552653, C01J17200, C01J 900, A61K 3159
Patent
active
051944316
ABSTRACT:
Vitamin D.sub.2 analogs in which a cyclopropane ring is introduced onto the 24-carbon of the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2 and 1.alpha.-hydroxyvitamin D.sub.2. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxy-vitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desirbed, such as osteoporosis.
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DeLuca Hector F.
Nakagawa Naoshi
Cintins Marianne M.
Kestler Kimberly J.
Wisconsin Alumni Research Foundation
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