24-and 25-substituted avermectin and milbemycin derivatives

Details 24-and 25-substituted avermectin and milbemycin derivatives 24-and 25-substituted avermectin and milbemycin derivatives

1989-10-30

1998-11-03

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514450, 536 71, 549264, A61K 3170, A61K 31335, C07D30000, C07H 1708

Patent

active

058308750

ABSTRACT:
Novel avermectin and milbemycin derivatives are disclosed, where the C-24 and C-25 carbon atoms are substituted by hydrogen, alkyl, alkenyl, substituted alkyl or substituted alkenyl groups. These compounds can be further substituted at the 4"-, 5-, 13-, and 23-positions. The new C-24 and C-25 substituted avermect prepared by cleavage of known and suitably protected avermectin and milbemycin compounds. The new compounds are potent anti-parasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.

REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
patent: 4171314 (1979-10-01), Chabala et al.
patent: 4173571 (1979-11-01), Chabala et al.
patent: 4199569 (1980-04-01), Chabala et al.
patent: 4206205 (1980-06-01), Mrozik et al.
patent: 4289760 (1981-09-01), Mrozik et al.
patent: 4310519 (1982-01-01), Albers-Schonberg et al.
patent: 4427663 (1984-01-01), Mrozik et al.
patent: 4806527 (1989-02-01), Christensen et al.
patent: 4849446 (1989-07-01), Asato et al.
patent: 4916120 (1990-04-01), Roben et al.
Chen et al (I) Abstr. Pep. Am. Chem. Soc. 1986 Meet MBTD 28 (1983).
Chen et al (II) Arch Biochen Biophys 269 pp. 544-547 (1989).
Schulman et al (I) J. Antibiot. 38 pp. 1494-1498 (1985).
Schulman et al (II) Antimicrobial Agents and Chemotherapy 31 pp. 744-747 (1987).
Fisher et al Macrolide Antibiotics Omura (Ed) Academic Press New York pp. 553-606 (1984).
Davies et al Nat. Prod. Rep. 3 pp. 87-121 (1986).
Shih, et al Tetrahedron Letters 31 pp. 3529-3532 (1990).
Shih, et al Tetrahedron Letters 31 pp. 3525-3528 (1990).

Affiliated with

Also associated with

Rating

24-and 25-substituted avermectin and milbemycin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 24-and 25-substituted avermectin and milbemycin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 24-and 25-substituted avermectin and milbemycin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-689252