Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1981-07-27
1982-08-17
Roberts, Elbert L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
26023955D, 2602395, C07J 1700
Patent
active
043448887
ABSTRACT:
A 24,25-dihydroxycholestane derivatives of the formula ##STR1## wherein A is a steroid residue and R is an aryl group and a process for preparation of the same are disclosed. The derivatives are an intermediate for synthesis of 24,25-dihydroxycholecalciferol having useful physicological activity like that of vitamin D.sub.3. 24,25-Dihydroxycholecalciferol can be produced in an industrially advantageous method via the intermediate which is easily prepared from commercially available starting compounds.
REFERENCES:
patent: 4028349 (1977-06-01), Partridge et al.
patent: 4204995 (1980-05-01), Barner et al.
Seki, M., et al. "Synthesis of Active Forms of Vitamin D VI.sup.1 Synthesis of (24R)-and (24S)-24,25-Dihydrpxyvitamin D.sub.3 ", Tetrahedron Letters, No. 1, pp. 15-18, 1975.
Isheguro, M., et al. "Studies on Steroids. LI. Stereoselective Introduction of 22-and 24-Hydroxyl Function in the Steroidal Side Chain", Chem. Pharm. Bull., 26 (12) 3715-3721 (1978).
Lam, H. Y., et al. "24,25-Dihydrovitamin D.sub.3. Synthesis and Biological Activity", Biochemistry, vol. 12, No. 24, 4851-4855 (1973).
Ohmori Masayuki
Takayama Hiroaki
Yamada Sachiko
Chugai Seiyaku Kabushiki Kaisha
Roberts Elbert L.
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