24,24-difluoro-26,27-dimethylvitamin D.sub.3 derivatives

Details 24,24-difluoro-26,27-dimethylvitamin D.sub.3 derivatives 24,24-difluoro-26,27-dimethylvitamin D.sub.3 derivatives

1986-05-30

1989-09-19

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

2603972, A61K 3159, A61K 3156

Patent

active

048681652

ABSTRACT:
24,24-Difluoro-26,27-dimethylvitamin D.sub.3 derivatives represented by formula: ##STR1## wherein X represents a hydrogen atom or a hydroxyl group. These compounds are prepared by irradiating 24,24-difluoro-26,27-dimethylcholesta-5,7-diene-(1.alpha.,)3.beta., 25-di- or triol with ultraviolet light, and is useful for the prevention or treatment of, for example, calcium pathobolism or osteoporosis.

REFERENCES:
patent: 4225596 (1980-09-01), De Luca
patent: 4521410 (1985-06-01), Holick et al.
Chemical Abstracts, vol. 103 (1985) #71584z; Sai et al.

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