24,24-Difluoro-25-hydroxycholecalciferol

Details 24,24-Difluoro-25-hydroxycholecalciferol 24,24-Difluoro-25-hydroxycholecalciferol

1979-03-05

1980-04-01

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 900

Patent

active

041961331

ABSTRACT:
The invention provides a new derivative of vitamin D.sub.3, 24,24-difluoro-25-hydroxycholecalciferol.
The compound is characterized by vitamin D-like activity in its ability to increase intestinal calcium transport, increase serum calcium and inorganic phosphorous concentration and to prevent the development of rickets. It would find ready application as a substitute for vitamin D.sub.3 and in the treatment of disease states evincing calcium-phosphorous imbalance and which are non-responsive to vitamin D.sub.3 therapy.

REFERENCES:
patent: 3993675 (1976-01-01), Uskokovic et al.
patent: 4069321 (1978-01-01), Jones et al.

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