24,24-Difluoro-1.alpha.,25-dihydroxycholecalciferol

Details 24,24-Difluoro-1.alpha.,25-dihydroxycholecalciferol 24,24-Difluoro-1.alpha.,25-dihydroxycholecalciferol

1979-03-28

1980-05-06

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568665, 424343, C07C 3532

Patent

active

042018811

ABSTRACT:
The invention provides new derivatives of vitamin D, 24,24-difluoro-1.alpha.,25-dihydroxycholecalciferol and 24,24-difluoro-1.alpha.,25-dihydroxy-5,6-trans-cholecalciferol and processes for preparing the same.
The compounds are characterized by vitamin D-like activity essentially equivalent to the vitamin D-like activity of 1.alpha.,25-dihydrocholecalciferol which is considered to be the hormonal form and most active derivative of vitamin D. The compounds of this invention are characterized by their ability to increase intestinal calcium transport, increase serum calcium and to prevent the development of rickets. These compounds would find ready application as a substitute for vitamin D and in the treatment of disease states evincing metabolic calcium and phosphorus deficiencies.

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