230Kd antigen present in Leishmania species

Details 230Kd antigen present in Leishmania species 230Kd antigen present in Leishmania species

1994-07-28

1998-02-17

Caputa, Anthony C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530350, 530395, 4241911, 4242651, 4242661, A61K 3817, A61K 39008, C07K 1444

Patent

active

057192634

ABSTRACT:
There is disclosed an isolated 230 Kd antigen which is present in Leishmania chagasi and Leishmania donovani, and an isolated polypeptide comprising one or a plurality of K39 repeat antigens. Also disclosed are DNAs encoding the 230 Kd antigen and the K39 repeat antigen, and vaccine compositions comprising the antigens.

REFERENCES:
Burns et al., Proc. Natl. Acad. Sci. USA 90:775; 1993.
Zhang et al., J. Clin. Microbiol. 30:2788; 1992.
Reed et al., Am. J. Trop. Med and Hygiene 43:632; 1990.
Reed et al., J. Immunol. 138:1596; 1987.
Russo et al., J. Immunol. 147:3575; 1991.
Jaffe and Zallis, Mol. Biochem. Parasitol. 27:53; 1988.
Sheppard and Dwyer, Mol. Biochem. Parasitol. 19:35; 1986.
Wallace et al., Infec. Immun. 60:2688; 1992.
Blaxter et al., Mol. Biochem. Parasitol. 30:259; 1988.
Miller et al., Mol. Biochem. Parasitol. 39:267; 1990.
Sigma Catalog, pp. 1546-1548 1990.

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