Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1985-10-25
1987-04-28
Siegel, Alan
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C07H 1708
Patent
active
046615881
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl, lower alkoxycarbonyl-lower alkyl, phenyl, phenyl substituted by one or more lower alkyl or halogen, phenyl-lower alkyl optionally substituted in its side chain by lower alkyl or lower alkoxycarbonyl, thienylmethyl or thiazolyl, R.sub.2 is hydrogen or lower alkyl, or ##STR2## constitutes a 3-7-membered nitrogen-containing heterocyclic ring in which R.sub.1 and R.sub.2 are connected, R.sub.3 is hydrogen or hydroxyl, and X is oxygen or sulfur, or a non-toxic salt thereof. These compounds have stronger antibacterial activity as compared with known clinically used macrolide antibiotics such as erythromycin, oleandomycin, josamycin and leucomycin, and also have strong antibacterial activity against all macrolide antibiotic-resistant strains such as macrolide-resistant A group strains (clinical isolates or erythromycin, oleandomycin and 16-membered macrolide antibiotic resistant strains). These compounds are also stable in vivo and hence may be used for treatment of infectious diseases and also are useful for feed additives and growth stimulants.
REFERENCES:
Tetrahedron Letters, No. 54, pp. 4737-4740, 1970, "The Structure of Tylosin.sup.1,2 " by R. B. Morin et al.
The Journal of Antibiotics, vol. XXXIV, No. 10, pp. 1374-1376, "Syntheis of 4'-Deoxymycaminosyl Tylonolide".
Merck Index, 9th ed., pp. 8007-8016.
Remington's Pharm. Science, 15th ed., pp. 1122-1124.
Fujiwara Tatsuro
Hirano Takao
Honda Eiichi
Ohta Kazuyo
Sakakibara Hideo
Siegel Alan
Toyo Jozo Kabushiki Kaisha
LandOfFree
23-O-substituted carbamoyl-23-demycinosyldesmycosin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 23-O-substituted carbamoyl-23-demycinosyldesmycosin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 23-O-substituted carbamoyl-23-demycinosyldesmycosin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-478084