23-nor-23-oxa avermectin analogs are active anthelmintic agents

Details 23-nor-23-oxa avermectin analogs are active anthelmintic agents 23-nor-23-oxa avermectin analogs are active anthelmintic agents

1992-03-18

1993-09-14

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514450, 536 71, 549264, A61K 3171, A61K 31365

Patent

active

052448797

ABSTRACT:
Avermectin analogs are prepared where the 23-position ring carbon atom is deleted and replaced by an oxygen atom. The compounds are prepared by opening the outer spiroketal ring to gain access to the 23-position atom, substituting the ring-opened compounds with a substituent containing the oxygen atom in the appropriate position and closing the ring to prepare the desired compounds. The compounds are potent anthelmintic agents and methods and compositions including such 23-nor-23-oxa compounds are also disclosed.

REFERENCES:
patent: 4199569 (1980-04-01), Chabala et al.
patent: 4310519 (1982-01-01), Albers-Schonberg et al.

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