23 Kd human retinal CAR antigen

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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435 691, 435325, 536 235, C07K 14435, C12H 1509

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active

057864519

ABSTRACT:
A purified polypeptide having an amino acid sequence SEQ ID NO: 1, which is a human retinal cancer-associated retinopathy antigen capable of selectively binding to antibodies present in a body fluid of a human patient afflicted with cancer associated retinopathy. A recombinant 23 kDa polypeptide which is recombinantly synthesized human retinal cancer-associated retinopathy antigen having an amino acid sequence SEQ ID NO: 1.

REFERENCES:
patent: 5405749 (1995-04-01), Polans
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The Cancer-Associated Retinopathy antigen is Recoverin-like Protein, by Charles E. Thirkill, et al., Investigative Ophthalmology & Visual Science, vol. 33, No. 10, Sep. 1992, pp. 2768-2772.
Sambrook et al., "Molecular Cloning, A Laboratory Manual", Cold Spring Harbor Laboratory Press, vol. 3 pp. 16.2-16.31 1989.
Young et al., Proc. Natl. Acad. Sci., vol. 80, 1194-1198, 1983.
Thirkill, Charles E. et al., "Antibody Indications of Secondary and Superinposed Retinal Hypersensitivity in Retinitis Pigmentosa." J. Opthalmology. 112:132-137 (1991).
Jacobson, Daniel M. et al., "A Clinical Triad to Diagnose Paraneoplastic Retinopathy." Annals of Neurology, 28:162-167 (1990).
Thirkill, Charles E. et al., "Cancer-Associated Retinopathy (CAR Syndrome) with Antibodies Reacting with Retinal, Optic-Nerve, and Cancer Cells." New England J. of Medicine 321:1589-1594 (1989).
Thirkill, Charles E. et al., "Circulating and Localized Immune Complexes in Experimental Mycoplasma-Induced Arthritis-Associated Ocular Inflammation." Infection and Immunity. 60:401-405(1992).
Keltner, John L. et al., "Management and Monitoring of Cancer-Associated Retinopathy." Arch Ophthalmol. 110:48-53 (1992).
Thirkill, Charles E. et al., "Cloning and Sequencing of the 23 Kd Retinal Car Antigen." ARVO 1310-48(1991).
Dizhoor, Alexander M. et al, "Recoverin: A Calcium Sensitive Activator of Retinal Rod Guanylate Cyclase." Science. 915-918(Feb. 1991).
Polans, Arthur S. et al. "A Photoreceptor Calcium Binding Protein Is Recognized by Autoantibodies Obtained from Patients with Cancer-associated Retinopathy" J. Cell Biology 112:981-989(1991).
Thirkill, Charles E., et al. "Cancer-Associated Retinopathy" Arch-Opthalmol 105:372-375(1987).

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