Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-03-18
1998-07-28
Teng, Sally P.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 435325, 536 235, C07K 14435, C12H 1509
Patent
active
057864519
ABSTRACT:
A purified polypeptide having an amino acid sequence SEQ ID NO: 1, which is a human retinal cancer-associated retinopathy antigen capable of selectively binding to antibodies present in a body fluid of a human patient afflicted with cancer associated retinopathy. A recombinant 23 kDa polypeptide which is recombinantly synthesized human retinal cancer-associated retinopathy antigen having an amino acid sequence SEQ ID NO: 1.
REFERENCES:
patent: 5405749 (1995-04-01), Polans
Darnell et al., Molecular Cell Biology, pp. 54, 55, and 258-260, Scientific American Books, 1986.
The Cancer-Associated Retinopathy antigen is Recoverin-like Protein, by Charles E. Thirkill, et al., Investigative Ophthalmology & Visual Science, vol. 33, No. 10, Sep. 1992, pp. 2768-2772.
Sambrook et al., "Molecular Cloning, A Laboratory Manual", Cold Spring Harbor Laboratory Press, vol. 3 pp. 16.2-16.31 1989.
Young et al., Proc. Natl. Acad. Sci., vol. 80, 1194-1198, 1983.
Thirkill, Charles E. et al., "Antibody Indications of Secondary and Superinposed Retinal Hypersensitivity in Retinitis Pigmentosa." J. Opthalmology. 112:132-137 (1991).
Jacobson, Daniel M. et al., "A Clinical Triad to Diagnose Paraneoplastic Retinopathy." Annals of Neurology, 28:162-167 (1990).
Thirkill, Charles E. et al., "Cancer-Associated Retinopathy (CAR Syndrome) with Antibodies Reacting with Retinal, Optic-Nerve, and Cancer Cells." New England J. of Medicine 321:1589-1594 (1989).
Thirkill, Charles E. et al., "Circulating and Localized Immune Complexes in Experimental Mycoplasma-Induced Arthritis-Associated Ocular Inflammation." Infection and Immunity. 60:401-405(1992).
Keltner, John L. et al., "Management and Monitoring of Cancer-Associated Retinopathy." Arch Ophthalmol. 110:48-53 (1992).
Thirkill, Charles E. et al., "Cloning and Sequencing of the 23 Kd Retinal Car Antigen." ARVO 1310-48(1991).
Dizhoor, Alexander M. et al, "Recoverin: A Calcium Sensitive Activator of Retinal Rod Guanylate Cyclase." Science. 915-918(Feb. 1991).
Polans, Arthur S. et al. "A Photoreceptor Calcium Binding Protein Is Recognized by Autoantibodies Obtained from Patients with Cancer-associated Retinopathy" J. Cell Biology 112:981-989(1991).
Thirkill, Charles E., et al. "Cancer-Associated Retinopathy" Arch-Opthalmol 105:372-375(1987).
Teng Sally P.
The Regents of the University of California
Verny Hana
LandOfFree
23 Kd human retinal CAR antigen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 23 Kd human retinal CAR antigen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 23 Kd human retinal CAR antigen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-24445