23-deoxy-27-chloro derivatives of LL-F28249 compounds

Details 23-deoxy-27-chloro derivatives of LL-F28249 compounds 23-deoxy-27-chloro derivatives of LL-F28249 compounds

1987-03-06

1990-09-11

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

A61K 31335, C07D31306

Patent

active

049564790

ABSTRACT:
The present invention relates to novel derivatives of LL-F28249 compounds. These LL-F28249 compounds preferably are derived via a controlled microbiological fermentation of Streptomyces cyaneogriseus subspecies noncyanogenus having deposit accession number NRRL 15773. The 23-deoxy-27-halo(chloro) derivatives have the 23-hydroxy group of the LL-F28249 compounds replaced by hydrogen and a halogen such as chlorine in the 27-position with the double bond shifted to the 26,26'-position. The novel derivatives of the present invention possess activity as anthelmintic, ectoparasitic, insecticidal, acaricidal and nematicidal agents and are useful in areas of human and animal health and in agricultural crops. Compositions containing the present compounds also are presented herein.

REFERENCES:
patent: Re32034 (1985-11-01), Chabala et al.
patent: 4584314 (1986-04-01), Burckhardt
patent: 4696922 (1987-09-01), Sturm et al.

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