23,23-Difluoro-25-hydroxy-vitamin D.sub.3 and process for prepar

Details 23,23-Difluoro-25-hydroxy-vitamin D.sub.3 and process for prepar 23,23-Difluoro-25-hydroxy-vitamin D.sub.3 and process for prepar

1983-08-18

1985-02-19

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603971, 26023955R, C07J 900

Patent

active

045004609

ABSTRACT:
The invention provides a new derivative of vitamin D, 23,23-difluoro-25-hydroxycholecalciferol, a method for preparing said compound and various new intermediates utilized in such process.
The compound is characterized by vitamin D-like activity as evidenced by its ability to increase intestinal calcium transport and serum calcium. It is further characterized by its resistance to hydroxylation at C-23, which is recognized as an essential metabolic step to the inactivation of vitamin D, and therefore should provide vitamin D-like activity of greater time duration.

REFERENCES:
patent: 4196133 (1980-04-01), DeLuca et al.
patent: 4226788 (1980-10-01), DeLuca et al.
patent: 4397847 (1983-08-01), Boris et al.

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