23,23-Difluoro-1.alpha.,25-dihydroxy-vitamin D.sub.3

Details 23,23-Difluoro-1.alpha.,25-dihydroxy-vitamin D.sub.3 23,23-Difluoro-1.alpha.,25-dihydroxy-vitamin D.sub.3

1983-08-18

1985-03-05

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 900

Patent

active

045029911

ABSTRACT:
The invention provides a new derivative of vitamin D, 23,23-difluoro-1,25-dihydroxycholecalciferol.
The compound is characterized by vitamin D-like activity as evidenced by its ability to increase intestinal calcium transport. It is further characterized by its resistance to hydroxylation at C-23, which is recognized as an essential metabolic step to the inactivation of vitamin D, and therefore should provide vitamin D-like activity of greater time duration.

REFERENCES:
patent: 4284577 (1981-08-01), Yamada et al.

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