22025, a novel human cyclic nucleotide phosphodiesterase

Details 22025, a novel human cyclic nucleotide phosphodiesterase 22025, a novel human cyclic nucleotide phosphodiesterase

1999-06-11

2000-11-14

Sisson, Bradley L.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

4352523, 4353201, 536 232, 536 235, 536 2431, C12N 120, C12N 1500, C07H 2104

Patent

active

061468762

ABSTRACT:
The present invention relates to a newly identified human cyclic nucleotide phosphodiesterase belonging to the superfamily of mammalian phosphodiesterases. The invention also relates to polynucleotides encoding the phosphodiesterase. The invention further relates to methods using the phosphodiesterase polypeptides and polynucleotides as a target for diagnosis and treatment in phosphodiesterase-mediated or -related disorders. The invention further relates to drug-screening methods using the phosphodiesterase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the phosphodiesterase polypeptides and polynucleotides. The invention further relates to procedures for producing the phosphodiesterase polypeptides and polynucleotides.

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